Diverse metabolic model parameters generate similar methionine cycle dynamics
نویسندگان
چکیده
منابع مشابه
Diverse metabolic model parameters generate similar methionine cycle dynamics.
Parameter estimation constitutes a major challenge in dynamic modeling of metabolic networks. Here we examine, via computational simulations, the influence of system nonlinearity and the nature of available data on the distribution and predictive capability of identified model parameters. Simulated methionine cycle metabolite concentration data (both with and without corresponding flux data) wa...
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ژورنال
عنوان ژورنال: Journal of Theoretical Biology
سال: 2008
ISSN: 0022-5193
DOI: 10.1016/j.jtbi.2007.12.009